11 Best Natural Supplements For Depression

Natural Supplements for depression and anxiety are my go-to remedies that work. Conventional medication didn’t work for me, and many other people are not finding the relief they need. 

I suffer from depression and would instead sort my supplements into a container than talk to some therapist every day about why I can’t shut off the negative thoughts. I’m doing much better now that I’m using natural supplements for depression. 

Natural supplements for depression

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Natural Supplements For Depression

I went to see a holistic doctor earlier this year because I wanted to come off my medications. My doctor insists on using the third party tested supplements such as on ConsumerLab.com.  The doctor also gave me a list of manufacturers she trusted, such as:

  • Nature Made
  • Vital Nutrients
  • Carlson Labs
  • Douglas Labs
  • Prothera
  • Klaire Labs
  • Metagenics

Supplements We Recommend

Some quick facts about depression:

  • Nearly 7% of the American population is suffering from a major depressive disorder
  • Almost 40 million people being diagnosed with anxiety disorders. 
  • Scientists and researchers have begun to question the efficacy of these antidepressant medications.
  • Studies have also found a significant increase in antidepressant drug misuse and abuse, causing people to seek more information on natural supplements for depression.

The following natural supplements for depression are extensively studied and used for treating symptoms of anxiety and depression. They have been found to have fewer side effects and are effectively bringing about the required positive results.

Before using any supplement, always consult your doctor first.

1. Omega-3 Fatty Acids:

omega-3 fatty acid (EPA)

I’ll admit, taking Omega 3 is my go-to supplement that makes the most difference in my mood. I prefer the OmegaBrite brand as their capsules contain 70 percent EPA (eicosapentaenoic acid).

 I’ve used other brands that were higher in DHA, which didn’t help so much, but as soon as I switched to a higher EPA to DHA ratio, my moods were so much happier. Studies show that EPA does more to lift our spirits than DHA.

Omega-3 Fatty Acids are an important antidepressant source. It is a suitable type of fat available naturally in fishes such as salmon, trout, and sardines. It is also available in supplement form and sold as “Fish Oil Capsules.” 

According to studies, people who do not get enough of Omega-3 fatty acids in their food are bound to suffer from depression. Eating fish (that contain this healthy fat) at least three times a week can help keep depression at bay. Those who do not consume fish can receive omega-3 fatty acids in the form of fish oil capsules.

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2.  Probiotics:

probiotics supplements

Recent studies have identified an important relationship between the human brain and the gut.

The human gut manufactures about 80 to 90 % of the body’s serotonin – an important neurotransmitter that regulates our moods. There is constant communication between the brain and the gut.

Related: 21 Natural Supplements For Anxiety And Panic Attacks

This explains why anxiety and depression trigger gastrointestinal symptoms like constipation and diarrhea and why digestive disorders trigger symptoms of anxiety and depression.

Consuming probiotics has been found to relieve symptoms of anxiety and depression greatly. Probiotics are naturally available in food like these and are also available in supplement form as shown here.

3.  B-Complex Vitamins:

B complex

According to bestselling author Mark Hyman, Vitamin B-6, Vitamin B12, and folic acid are the “Mighty methylators for mental health.”

According to this study mentioned in the American Journal of Psychiatry, around 27% of severely depressed women were found to be deficient in Vitamin B-12.

Therefore, indicating the effectiveness of Vitamin B-12 shots in the cure of severe cases of depression.

Other studies pointed out the usefulness of Vitamin B6 and folic acid in helping relieve symptoms of mild depression and increasing the efficacy of prescription antidepressants.

These supplements effectively help relieve symptoms of depression and can be taken in liquid form as well as capsules.

4.  SAM-e (S-adenosylmethionine):

sam-e supplement

SAM-e is a chemical compound produced naturally in the human body. It powers over 200 enzymes necessary for healthy cell growth and maturation.

In the brain, SAM-e is required for nerve cells to make energy, maintain connectivity, and generate mood-related neurotransmitters.

Our body also uses this compound for pain relief, depression, liver diseases, and other conditions.

People who don’t make enough Sam-e naturally can be helped by taking a supplement.

A 2002 review conducted by the U.S. Agency for Healthcare Research and Quality found SAM-e supplements to be equally effective as antidepressants.

Also, other studies have found that taking SAM-e along with prescribed antidepressants have helped bring about desired results in people who have not responded to medication.

Related: 41 Pick Me Ups When You’re Having A Bad Day

 In the United States, a synthetic version of this compound is available as a dietary supplement whereas in Europe this compound is available as a prescription drug.

5.  Turmeric (Curcuma Longa):


Turmeric is a common kitchen spice used for cooking and seasoning. This spice is extensively used in Indian and Chinese cuisines and medicine.

Turmeric is known for its anti-inflammatory properties as well as its ability to produce antioxidants.

According to Adrian Lopresti, a clinical psychologist, and researcher at the School of Psychology and Exercise Science at Murdoch University- “Turmeric has relevance to depression because people with depression have greater inflammation and oxidative stress, which can affect all major organs in the body, including the brain.”

Chronic inflammation tends to decrease levels of two critical neurotransmitters -serotonin and dopamine, which may lead to degeneration in some regions of the brain.

Taking turmeric supplements can help reduce this inflammation and restore these neurotransmitters, thus, protecting the brain and eventually leading to improvements in mood.

6.  Vitamin D:

vitamin D supplement

Vitamin D is a fat-soluble vitamin that is produced in the human body when our body is exposed to sunlight. It is present in very few foods and is available as a dietary supplement. This vitamin plays a vital role in promoting bone and cell growth.

It also helps in the body’s immunity and neuromuscular function. A lot of studies have found an increased association between depression and Vitamin D deficiencies.

Many theories are formulated on the workings of Vitamin D in the brain. One such theory states that Vitamin D increases the number of monoamines in the brain, which helps treat depression.

7.  Vitamin C:

vitamin c

Vitamin C is an important antioxidant that strengthens one’s immunity as well as combats the effects of oxidative stress in our body. Research and studies have shown that oxidative stress can trigger neuropsychological disorders in the body.

Oxidative stress, according to research, is also one of the leading causes of anxiety and depression in individuals.

Deficiencies in Vitamin C lead to decreased levels of dopamine and serotonin in the brain, which again trigger symptoms of anxiety and depression in an individual.

Taking Vitamin C supplements helps minimize the damage caused by oxidative stress and reverse the symptoms of depression and anxiety.

Human beings do not produce this vitamin naturally in their bodies.

Apart from being absorbed through particular food, this vitamin needs to be taken additionally through supplements to combat depression and anxiety.

8.  Amino Acids:

amino acid molecules

Lack of amino acids in the body limits the brain’s functioning and makes the body slow, sluggish, and unfocused, thereby increasing symptoms of anxiety and depression.

According to Dr. Hyman, “ALL of the thousands of molecules in your body are built from only eight essential amino acids that we must get from our diet.” There is significant research showing a correlation between the lack of amino acids and psychological disorders.

Amino acid supplements help restore the brain’s chemistry and significantly reduce symptoms of anxiety and depression.

9.  St John’s Wort:

st johns wort tea

St John’s Wort is a yellow-flowered plant and is also known as Hypericum perforatum. Used for medicinal and treatment purposes for depression, anxiety, and sleep disorders for a very long time.

Research and studies have shown that the extracts from this plant help regulate mood by increasing the level of certain chemical compounds in the brain.

St John’s Wort is extremely useful in reducing symptoms of mild and moderate depression. This medicinal herb is available as a capsule, tea, or liquid extract.

10.  GABA:

gaba molecule

Gamma-aminobutyric acid (GABA) is one of the body’s most essential neurotransmitters whose main functions involve inhibition and stress relief. This neurotransmitter plays a vital role in calming the nervous system.

GABA supplements are available in the form of pills, capsules, and powder. Low levels of GABA have been increasingly linked with depression and anxiety.

Research and studies point out the usefulness of GABA in helping treat symptoms of depression, anxiety, sleep disorders, and insomnia.

11.  Magnesium: 

Magnesium supplement

Magnesium is essential for the body because, without it, we would die. According to research about up to half of Americans do not get enough Magnesium. Caffeine, alcohol, sugar, and daily stress depletes these levels in our bodies. 
You can either eat a bunch of seaweed or green beans every day or take a daily natural supplement. Go to your nutritionist to ask about the dosage and then go to the local grocery store or even Amazon to buy a bottle.

 Magnesium is one of the most powerful stress reducers there is. 

The above mentioned natural supplements for depression are safe to use and are being tried by many. If you suffer from symptoms of depression, consider using these natural supplements to receive the necessary relief you need.

Related: Magnesium Relieves Anxiety And Panic Attacks

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Natural Supplements For Depression



One Comment

  1. Wonderful information you have out there, I’ve used these supplements most of my adult life. So glad i came across your post thank you, I’m going out tomorrow and getting some. Because I’m more depressed than any time in my life.

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